These patients are left with no other therapeutic options to achieve seizure control. Only a proportion of patients that are resistant to AED, may be candidates for surgery or neuromodulation such as vagus nerve stimulation (VNS).
Bryan maclever architecture trial#
The data shows the efficacy of anti-epileptic drugs (AEDs) in achieving seizure freedom, reduces from around 45% with the trial of the first AED to just 7% for the trial of the third AED. The road to this diagnosis is long and cumbersome. About 30% to 35% of people living with epilepsy are diagnosed with uncontrolled or partially controlled seizures. Epilepsy affects about one percent of the world’s population. Objective counting of seizures is essential in the diagnosis and treatment of epilepsy. Epilepsy causes unprovoked seizures, which can briefly disturb the brain’s electrical activity and cause temporary interruption or changes in bodily functions, movement, awareness, behavior, or feelings. Our proposed lead-free EEG recording solution may lead to a less invasive surgical placement through volume reduction and improve EEG recording quality.Įpilepsy is one of the most common, complex, and widely misunderstood neurological disorders, impacting people of all ages and genders. Moreover, lead wires and the associated feedthrough connectors are bulky. Lead wires have posed a significant challenge from a device reliability and measurement quality perspective. Our results suggest that compared to the conventional side-by-side electrode configuration, the source signal can be recorded reliably. The efficacy of the proposed electrode architecture is investigated through finite element modeling, phantom measurements, and cadaver studies.
Compared to the current side-by-side approaches with an electrode spacing of several cm, our proposed approach results in at least one order of magnitude reduction in volume. A back-to-back electrode configuration with an electrode spacing of less than 1 mm is proposed. This work introduces a novel electrode architecture for subgaleal EEG recording, which forgoes the need for lead wires. Current sgEEG solutions share a need for at least a 10 cm long lead wire, resulting in a bulky and invasive device. Subgaleal EEG (sgEEG) has emerged as an essential tool for long-term monitoring over several years. In the case of neurological conditions with intermittent episodes, such as epilepsy, long-term EEG monitoring outside the clinics and in the community setting is vital. Electroencephalography (EEG) has been widely used to understand the nervous system and as a clinical diagnostic tool.
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